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JCCC Member Directory

Samuel French, M.D., Ph.D.
Samuel French, M.D., Ph.D.

Specialty:

Pathology

General Information:

Gender:
Male
Language(s):
English

Affiliation(s):

Assistant Professor, Department of Pathology and Laboratory Medicine
Physician, Department of Pathology and Laboratory Medicine, Surgical Pathology, Gastroenterology/Liver Pathology
Member, Molecular Biology Institute
Member, JCCC Cancer and Stem Cell Biology Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center

Education:

Residency:
Pathology, UCLA School of Medicine, 1999 - 2002
Internship:
Pathology, UCLA School of Medicine, 1998 - 1998
Medical Degree:
M.D., University of Pittsburgh School of Medicine, 1997
Degree:
Ph.D., University of Pittsburg, 1996

Certification(s):

Medical Board Certification(s):
Anatomic Pathology, American Board of Pathology, 2002

Contact Information:

Surgical Pathology:
(310) 794-9450 Information and referral
Gastroenterology/Liver Pathology:
(310) 794-9450 Information and referral
(310) 267-2680 Referring physician
Phone:
(310) 267-2795 Office
Email:
sfrench@mednet.ucla.edu

Scientific Interest(s):

Dr. Samuel French studies hepatitis C viral mediated hepatocarcinogenesis, primarily focusing on a proteomic approach to determine how specific viral proteins subvert normal hepatocyte signaling. He is also interested in identifying gene expression changes seen in early hepatocyte dysplasia.

Selected Cancer-Related Publications:

Gonzalez O, Fontanes V, Raychaudhuri S, Loo R, Loo J, Arumugaswami V, Sun R, Dasgupta A, French SW. The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology. 2009 Dec;50(6):1756-64.

Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA. TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10175-80. Epub 2007 Jun 4.

French SW, Dawson DW, Chen HW, Rainey RN, Sievers SA, Balatoni CE, Wong L, Troke JJ, Nguyen MT, Koehler CM, Teitell MA. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. Cancer Lett. 2007 Apr 18;248(2):198-210. Epub 2006 Aug 28.

Chen HW, Rainey RN, Balatoni CE, Dawson DW, Troke JJ, Wasiak S, Hong JS, McBride HM, Koehler CM, Teitell MA, French SW. Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis. Mol Cell Biol. 2006 Nov;26(22):8475-87. Epub 2006 Sep 11.

French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA. A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane. Biochemistry. 2002 May 21;41(20):6376-82.

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