Dr. David Chia's major research interest is in the development of bio-markers for the early detection of cancers. Chia and his colleagues are involved in two National Cancer Institute (NCI)-sponsored studies designed to evaluate the efficacy of screening a population of normal individuals for a variety of tumor-associated markers in reducing mortality from prostate, lung, colon and ovarian cancers. The researchers measure the prostate-specific antigen, PSA, and another cancer antigen, Ca-125, levels in a large normal population as part of a national study, but are interested in several other tumor markers as well.
Chia is also a member of the Early Detection Research Network (EDRN), a scientific consortium sponsored by NCI, which will develop and validate molecular markers for earlier cancer detection and risk assessment and ready the tests for clinical use. Chia's laboratory serves as the bio-marker validation laboratory and is involved in technology development, quality control, refinement and high-throughput testing. The researchers have constructed tissue micro-array for prostate and breast cancers and are currently in the process of making a lung array.
Selected Cancer-Related Publications:
Andriole GL, Crawford ED, Grubb RL 3rd, Buys SS, Chia D, Church TR, Fouad MN, Gelmann EP, Kvale PA, Reding DJ, Weissfeld JL, Yokochi LA, O'Brien B, Clapp JD, Rathmell JM, Riley TL, Hayes RB, Kramer BS, Izmirlian G, Miller AB, Pinsky PF, Prorok PC, Gohagan JK, Berg CD; PLCO Project Team. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009 Mar 26;360(13):1310-9. Epub 2009 Mar 18.
Seligson DB, Horvath S, McBrian MA, Mah V, Yu H, Tze S, Wang Q, Chia D, Goodglick L, Kurdistani SK. Global levels of histone modifications predict prognosis in different cancers. Am J Pathol. 2009 May;174(5):1619-28. Epub 2009 Apr 6.
Marrero JA, Feng Z, Wang Y, Nguyen MH, Befeler AS, Roberts LR, Reddy KR, Harnois D, Llovet JM, Normolle D, Dalhgren J, Chia D, Lok AS, Wagner PD, Srivastava S, Schwartz M. Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma. Gastroenterology. 2009 Jul;137(1):110-8. Epub 2009 Apr 9.
Zhang L, Farrell JJ, Zhou H, Elashoff D, Akin D, Park NH, Chia D, Wong DT. Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer. Gastroenterology. 2010 Mar;138(3):949-57.e1-7. Epub 2009 Nov 18.
Yanagawa J, Walser TC, Zhu LX, Hong L, Fishbein MC, Mah V, Chia D, Goodglick L, Elashoff DA, Luo J, Magyar CE, Dohadwala M, Lee JM, St John MA, Strieter RM, Sharma S, Dubinett SM. Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma. Clin Cancer Res. 2009 Nov 15;15(22):6820-9. Epub 2009 Nov 3.