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JCCC Member Directory

James Wohlschlegel, Ph.D.
James Wohlschlegel, Ph.D.

Affiliation(s):

Associate Professor, Department of Biological Chemistry
Member, JCCC Gene Regulation Program Area

Contact Information:

Phone:
(310) 794-7955
Email:

Scientific Interest(s):

Dr. James Wohlschlegel and his colleagues research the use of proteomic mass spectrometry to study the regulatory networks mediated by the ubiquitin family of small protein modifiers. They are particularly interested in understanding the role of small ubiquitin-related modifier (SUMO) and ubiquitin in regulating chromatin structure and the cellular response to genotoxic stress.

Selected Cancer-Related Publications:

Stehling O, Vashisht AA, Mascarenhas J, Jonsson ZO, Sharma T, Netz DJ, Pierik AJ, Wohlschlegel JA, Lill R. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. Science. 2012 Jul 13;337(6091):195-9. Epub 2012 Jun 7

Lin JJ, Lehmann LW, Bonora G, Sridharan R, Vashisht AA, Tran N, Plath K, Wohlschlegel JA, Carey M. Mediator coordinates PIC assembly with recruitment of CHD1. Genes Dev. 2011 Oct 15;25(20):2198-209. Epub 2011 Oct 6

Lopez-Mosqueda J, Maas NL, Jonsson ZO, Defazio-Eli LG, Wohlschlegel J, Toczyski DP. Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature. 2010 Sep 23;467(7314):479-83.

Konopka G, Bomar JM, Winden K, Coppola G, Jonsson ZO, Gao F, Peng S, Preuss TM, Wohlschlegel JA, Geschwind DH. Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature. 2009 Nov 12;462(7270):213-7.

Vashisht AA, Zumbrennen KB, Huang X, Powers DN, Durazo A, Sun D, Bhaskaran N, Persson A, Uhlen M, Sangfelt O, Spruck C, Leibold EA, Wohlschlegel JA. Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science. 2009 Oct 30;326(5953):718-21. Epub 2009 Sep 17