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JCCC Member Directory

Gerald Lipshutz, M.D., D.D.S.
Gerald Lipshutz, M.D., D.D.S.

Specialty:

Kidney Transplantation
Liver Transplantation
Pancreas Transplantation
Surgery General

General Information:

Gender:
Male
Language(s):
English

Affiliation(s):

Associate Professor in Residence, Department of Surgery and Department of Urology
Physician, Department of Surgery, Liver and Pancreas Transplantation
Member, JCCC Tumor Immunology Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center

Education:

Medical Degree:
M.D., UCLA School of Medicine, 1993
D.D.S., UCLA School of Dentistry, 1985 - 1989
Degree:
M.S., UCLA Graduate Division, 1986 - 1990

Certification(s):

Board Certification(s):
Surgery, American Board of Surgery, 2003

Contact Information:

Phone:
(310) 825-8206
(310) 825-5318 Adult Liver and Intestinal Transplant referrals and patient appointments
(310) 206-6134 Pediatric Liver Transplant Referral
(310) 206-3748 Liver and Pancreas Transplantation referring physician
(310) 825-6301 Liver and Pancreas Transplantation medical center page operator
(310) 825-6836 Pancreas Transplant Referral
(310) 794-7788 Surgery patient appointments
Email:

Practice Information:

Clinical Interest(s):
Oncology
Transplantation in the Elderly
Kidney Transplantation
Liver Transplantation
Pancreas Transplantation
Pediatrics

Scientific Interest(s):

Achieving persistent transgene expression at therapeutic levels is a prerequisite for effective gene therapy for inherited disorders of intracellular or secreted proteins. In adult animals, delivery and expression of genes has resulted in immune responses to the gene product and to vector-associated proteins that limit or abrogate expression. Dr. Gerald Lipshutz's investigations aim to study the immune response to proteins expressed prenatally and on into adulthood, after in utero delivery of viral vectors expressing foreign transgenes. Re-administration of viral vectors during adulthood, after prenatal vector delivery, would allow for augmentation of expression postnatally with the goal of achieving therapeutic levels of gene expression. Understanding the mechanism of this immune unresponsiveness may also be important in the treatment of certain malignancies such as melanoma.

Selected Cancer-Related Publications:

Lipshutz GS, Hiatt J, Ghobrial RM, Farmer DG, Martinez MM, Yersiz H, Gornbein J, Busuttil RW. Outcome of liver transplantation in septuagenarians: a single-center experience. Arch Surg. 2007 Aug;142(8):775-81; discussion 781-4.

Lipshutz GS, Baxter-Lowe LA, Nguyen T, Jones KD, Ascher NL, Feng S. Death from donor-transmitted malignancy despite emergency liver retransplantation. Liver Transpl. 2003 Oct;9(10):1102-7.

Lipshutz GS, Titre D, Brindle M, Bisconte AR, Contag CH, Gaensler KM. Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero. Mol Ther. 2003 Jul;8(1):90-8.

Lipshutz GS, Brennan TV, Warren RS. Thorotrast-induced liver neoplasia: a collective review. J Am Coll Surg. 2002 Nov;195(5):713-8. Review.