Skip to page body Patient Care Survivorship Research Cancer Types News Giving Community Partners Clinical Trials
UCLA's Jonsson Comprehensive Cancer Center
Take the Jonsson Cancer Center Site Survey

JCCC Member Directory

Gregory S. Payne, Ph.D
Gregory S. Payne, Ph.D

Affiliation(s):

Professor, Department of Biological Chemistry
Member, ACCESS Department - Biological Chemistry, ACCESS Affinity - Cell Biology
Member, JCCC Cancer and Stem Cell Biology Program Area

Contact Information:

Phone:
(310) 206-3121
Email:
Website:

Scientific Interest(s):

Research in Dr. Gregory Payne's lab addresses mechanisms of clathrin-mediated protein traffic, with an emphasis on endocytosis and transport between the trans Golgi network and endosomes. Transport through these pathways is important for down-regulation of growth-signaling receptors and for maturation of growth factors and other molecules important for cell-cell communication. Because the process and molecular machinery of clathrin-mediated transport is conserved in eukaryotic cells, the Payne lab uses the budding yeast Saccaromyces cerevisiae as a model organism.

The Payne lab applies molecular genetics, systematic genome-wide genetic approaches, proteomics, chemical genetics and time-lapse live cell imaging to understand how clathrin coated vesicles are formed and how proteins are selected for transport in these vesicles.

Selected Cancer-Related Publications:

Mahadev RK, Di Pietro SM, Olson JM, Piao HL, Payne GS, Overduin M. Solution structure of Sla1 Homology domain 1 and interaction with the NPFxD endocytic internalization motif. EMBO J. 2007 Apr 4;26(7):1963-71. Epub 2007 Mar 15.

Duncan MC, Ho DG, Huang J, Jung ME, Payne GS. Composite synthetic lethal identification of membrane traffic inhibitors. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6235-40. Epub 2007 Apr 2.

Duncan MC, Costaguta G, Payne GS. Yeast epsin-related proteins required for Golgi-endosome traffic define a gamma-adaptin ear-binding motif. Nat Cell Biol. 2003 Jan;5(1):77-81.

Howard JP, Hutton JL, Olson JM, Payne GS. Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis. J Cell Biol. 2002 Apr 15;157(2):315-26. Epub 2002 Apr 8.

Pishvaee B, Costaguta G, Yeung BG, Ryanzatsev S, Greener T., Greene LE, Eisenberg E., McCaffery JM, Payne GS. A yeast DNA J protein required for uncoating of clathrin-coated vesicles in vivo. Nat Cell Biol. 2000 Dec;2(12):958-63.