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Kuk-Wha Lee, M.D., Ph.D.
Kuk-Wha Lee, M.D., Ph.D.


Pediatric Endocrinology

General Information:



Assistant Professor in Residence, Department of Pediatrics, Pediatric Endocrinology
Member, JCCC Cancer and Stem Cell Biology Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica


Pediatric Endocrinology, UCLA School of Medicine, 2000 - 2003
Pediatrics, Loma Linda Univ. Childrens Hospital, 1998 - 2000
Pediatrics, Loma Linda Univ. Childrens Hospital, 1997 - 1998
Medical Degree:
M.D., Loma Linda University School of Medicine, 1996
Ph.D., Loma Linda University, 1995


Board Certification(s):
Pediatric Endocrinology, American Board of Pediatrics, 2005
Pediatrics, American Board of Pediatrics, 2000

Contact Information:

(310) 825-6496

Scientific Interest(s):

Dr. Kuk-Wha Lee's research interests involve the study of Insulin-like growth factor binding proteins (IGFBPs). Over the past decade, IGFBPs have emerged as intrinsic effectors of cell growth and metabolism -- effects that can be unrelated to their ability to bind IGFs. She studies these molecules in a variety of eukaryotic systems and is involved in a clinical study to bring this to translation as a clinical therapy for men with prostate cancer. In addition, she is interested in the molecular mechanisms by which these molecules induce their tumor suppressive effects, and to that end studies protein partners and intracellular trafficking mechanisms as a means to understand their mode of action.

Selected Cancer-Related Publications:

Lee KW, Liu B, Ma L, Li H, Bang P, Koeffler HP, Cohen P. Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. J Biol Chem. 2004 Jan 2;279(1):469-76. Epub 2003 Oct 22.

Ali O, Cohen P, Lee KW. Epidemiology and Biology of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) as an anti-cancer molecule. Horm Metab Res. 2003 Nov-Dec;35(11-12):726-33.

Lee KW, Cohen P. Nuclear effects: unexpected intracellular actions of insulin-like growth factor binding protein-3. J Endocrinol. 2002 Oct;175(1):33-40.