Dr. Shen Hu's research interests are in the area of cancer proteomics/metabolomics focusing on understanding the molecular mechanisms and developing diagnostic/therapeutic applications using mass spectrometry and protein microarray technology. His lab is also studying Sjogren's syndrome, single cell proteomics and stem cell biology.
Selected Cancer-Related Publications:
Wang J, Christison TT, Misuno K, Lopez L, Huhmer AF, Huang Y, Hu S. Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap mass spectrometry. Anal Chem. 2014 May 20;86(10):5116-24. doi: 10.1021/ac500951v. Epub 2014 May 9.
Zhang M, Chai YD, Brumbaugh J, Liu X, Rabii R, Feng S, Misuno K, Messadi D, Hu S. Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes. BMC Cancer. 2014 Mar 25;14:223. doi: 10.1186/1471-2407-14-223.
Misuno K, Tran SD, Khalili S, Huang J, Liu Y, Hu S. Quantitative analysis of protein and gene expression in salivary glands of Sjogren's-like disease NOD mice treated by bone marrow soup. PLoS One. 2014 Jan 29;9(1):e87158. doi: 10.1371/journal.pone.0087158. eCollection 2014.
Arellano-Garcia ME, Misuno K, Tran SD, Hu S. Interferon-gamma Induces Immunoproteasomes and the Presentation of MHC I-Associated Peptides on Human Salivary Gland Cells. PLoS One. 2014 Aug 7;9(8):e102878. doi: 10.1371/journal.pone.0102878. eCollection 2014.
Misuno K, Liu X, Feng S, Hu S. Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells. Stem Cell Res Ther. 2013;4(6):156.