Dr. Percy Lee’s research interests are primarily translational. He has expertise in innovative approaches of delivering radiation therapy; these include intensity-modulated radiation therapy (IMRT), as well as stereotactic body radiation therapy (SBRT) and stereotactic radiosurgery (SRS) where highly focused radiation is concentrated on localized tumors. These approaches minimize radiation to surrounding normal tissue, thereby reducing side effects and improving tumor control. Lee is focused on developing novel functional image-guided radiation therapy approaches and discovering new molecularly targeted anti-angiogenic drugs for cancer therapy. In addition, he is investigating combining molecular targeted therapy with SBRT in a rational and innovative approach with the goal of improving treatment outcomes.
Selected Cancer-Related Publications:
La TH, Filion EJ, Turnbull BB, Chu JN, Lee P, Nguyen K, Maxim P, Loo BW, Quon A, Graves EE, Le QT. Metabolic Tumor Volume Predicts for Recurrences and Death in Head and Neck Cancer. Int J Radiat Oncol Biol Phys, 2008 72(1) , Pages S159 - S160.
Xie Y, Chao M, Lee P, Xing L. Feature-based rectal contour propagation from planning CT to cone beam CT. Med Phys. 2008 Oct;35(10):4450-9.
Lee P, Weerasuriya DK, Lavori PW, Quon A, Hara W, Maxim PG, Le QT, Wakelee HA, Donington JS, Graves EE, Loo BW Jr. Metabolic tumor burden predicts for disease progression and death in lung cancer. Int J Radiat Oncol Biol Phys. 2007 Oct 1;69(2):328-33.
Lee P, Goishi K, Davidson AJ, Mannix R, Zon L, Klagsbrun M. Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10470-5. Epub 2002 Jul 25.
Miao HQ, Lee P, Lin H, Soker S, Klagsbrun M. Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J. 2000 Dec;14(15):2532-9.