Dr. Dinesh Rao is interested in understanding the molecular underpinnings of cancer. Specifically, the processes by which the normal differentiation of cells is disrupted in cancer are of great interest. In this context, he is studying the role of microRNAs in hematopoiesis and malignancy. His research has led to the identification of several miRNA species important in acute myeloid leukemia. In addition, the exploration of these miRNAs as factors in hematopoietic development has helped to highlight the complex genetic networks that are co-opted by cancer cells. Novel diagnostic and therapeutic options are likely to be generated by the study of these important regulators of gene expression.
Selected Cancer-Related Publications:
Chaudhuri AA, So AY, Mehta A, Minisandram A, Sinha N, Jonsson VD, Rao DS, O'Connell RM, Baltimore D. Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4233-8. Epub 2012 Feb 24
Contreras J, Rao DS. MicroRNAs in inflammation and immune responses. Leukemia. 2012 Mar;26(3):404-13. Epub 2011 Dec 20
O'Connell RM, Zhao JL, Rao DS. MicroRNA function in myeloid biology. Blood. 2011 Sep 15;118(11):2960-9. Epub 2011 Jul 1
Zhao JL, Rao DS, Boldin MP, Taganov KD, O'Connell RM, Baltimore D. NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci U S A. 2011 May 31;108(22):9184-9. Epub 2011 May 16
Rao DS, O'Connell RM, Chaudhuri AA, Garcia-Flores Y, Geiger TL, Baltimore D. MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1. Immunity. 2010 Jul 23;33(1):48-59. Epub 2010 Jul 1