Cancer cells exhibit an altered metabolism compared to their normal cell counterparts. There is growing evidence that this altered metabolism is critical for tumor cell growth. Dr. Heather Christofk and colleagues are studying how metabolism is regulated in normal and cancer cells, and how this contributes to disease. They have discovered one mechanism important for the metabolic alterations in tumor cells, and are now exploring additional mechanisms of metabolic regulation. Their goals are to identify novel drug targets for cancer and other proliferative disorders, and to better define the role of metabolism for cell growth.
Selected Cancer-Related Publications:
Bensinger SJ, Christofk HR. New aspects of the Warburg effect in cancer cell biology. Semin Cell Dev Biol. 2012 Jun;23(4):352-61. Epub 2012 Mar 8
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 2008 Mar 13;452(7184):181-6.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008 Mar 13;452(7184):230-3.