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Gay M. Crooks, M.B., B.S.
Gay M. Crooks, M.B., B.S.

Specialty:

Pediatric Bone Marrow Transplantation

General Information:

Gender:
Female
Language(s):
English

Affiliation(s):

Professor, Department of Pediatrics, Department of Pathology and Laboratory Medicine
Member, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Co-Director, JCCC Cancer and Stem Cell Biology Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center

Education:

Fellowship:
Pediatric Hematology/Oncology, Childrens Hospital of Los Angeles, 1989 - 1993
Pediatrics, Fellow of Royal Australasian College of Physicians,1991
Residency:
Princess Margaret Hospital for Children, 1983 - 1984
Medical Degree:
M.B.,B.S. University of Western Australia, 1982

Certification(s):

Board Certification(s):
Fellow of Royal Australasian College of Physicians (FRACP), 1991

Contact Information:

Phone:
(310) 206-0205
Email:
Website:

Practice Information:

Clinical Interest(s):
Pediatric Bone Marrow Transplantation
Primary Immune Deficiencies

Scientific Interest(s):

Dr. Gay Crooks’ research program was founded on the question of how to identify and functionally define human hematopoietic stem and progenitor cells. This central theme has reached over time into three related areas: 1) the characterization and manipulation of human hematopoietic stem cells and lymphoid progenitors in cord blood, bone marrow and thymus; 2) mechanisms of engraftment and thymopoiesis after bone marrow transplantation; and 3) hematopoiesis from human embryonic stem cells. Specific areas of investigation include stem and lymphoid progenitor expansion using regulated Mpl receptor dimerization, VEGF-mediated angiogenesis in the neonatal thymus and lymphoid commitment during hESC differentiation.

Selected Cancer-Related Publications:

Parekh C, Sahaghian A, Kim W, Scholes J, Ge S, Zhu Y, Asgharzadeh S, Hollis R, Kohn D, Ji L, Malvar J, Wang X, Crooks G. Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors. Stem Cells. 2012 Apr;30(4):697-708.

Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM. Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Mol Ther. 2011 Apr;19(4):768-81. Epub 2010 Dec 21

Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13742-7. Epub 2010 Jul 19

Cuddihy AR, Ge S, Zhu J, Jang J, Chidgey A, Thurston G, Boyd R, Crooks GM. VEGF-mediated cross-talk within the neonatal murine thymus. Blood. 2009 Mar 19;113(12):2723-31. Epub 2008 Dec 16

Abdel-Azim H, Zhu Y, Hollis R, Wang X, Ge S, Hao QL, Smbatyan G, Kohn DB, Rosol M, Crooks GM. Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl. Blood. 2008 Apr 15;111(8):4064-74. Epub 2008 Jan 3