Dr. Erica Sloan studies neural regulation of metastasis. Her work focuses on the cellular and molecular mechanisms of sympathetic nervous system (SNS) regulation of breast cancer progression. Using live optical imaging technology, Sloan has identified novel neural-immune pathways that enhance metastasis and is currently investigating novel anti-metastatic therapies that target these pathways. Sloan is a Research Scientist at the UCLA Cousins Center within the Semel Institute for Neuroscience and Human Behavior. She completed a Bachelor of Science (Hons) at the Australian National University where she was awarded the University Medal in Biochemistry and Molecular Biology. Her Ph.D., at the Peter MacCallum Cancer Center in Melbourne, Australia, focused on mechanisms of breast cancer metastasis and helped to identify genes involved in the spread of cancer.
Selected Cancer-Related Publications:
Sloan EK, Priceman SJ, Cox BF, Yu S, Pimentel MA, Tangkanangnukul V, Arevalo JM, Morizono K, Karanikolas BD, Wu L, Sood AK, Cole SW. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Res. 2010 Sep 15;70(18):7042-52. Epub 2010 Sep 7.
Sloan EK, Ciocca DR, Pouliot N, Natoli A, Restall C, Henderson MA, Fanelli MA, Cuello-Carrión FD, Gago FE, Anderson RL. Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am J Pathol. 2009 Jun;174(6):2035-43. Epub 2009 May 1.
Sloan EK, Capitanio JP, Tarara RP, Mendoza SP, Mason WA, Cole SW. Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis. J Neurosci. 2007 Aug 15;27(33):8857-65.
Sloan EK, Pouliot N, Stanley KL, Chia J, Moseley JM, Hards DK, Anderson RL. Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone. Breast Cancer Res. 2006;8(2):R20. Epub 2006 Apr 11.
Sloan EK, Stanley KL, Anderson RL. Caveolin-1 inhibits breast cancer growth and metastasis. Oncogene. 2004 Oct 14;23(47):7893-7.