Research in Dr. Michael Collins' laboratory studies aspects of developmental toxicology or teratology. A common theme for many of the ongoing projects is the understanding of gene-environment interactions.
Collins' current projects include determining the chromosomal loci and eventually isolating the genes responsible for a murine strain difference in the induction of forelimb defects by cadmium or retinoic acid using quantitative trait loci (QTL) analysis, gene expression profiling, and proteomics; fine mapping as a prelude to positionally cloning a gene on mouse chromosome 3 (cdm) that was determined to cause resistance to cadmium-induced testicular toxicity and sensitivity to cadmium-induced forelimb defects; gene-gene and gene-environment interactions in the induction of teratogenesis with a mutant form of the mouse Pax3 gene (aka Splotch); and studies to determine the role of retinoids in normal and abnormal neural tube closure via analyses of the nuclear receptors and interactions with genes and nutrients.
Selected Cancer-Related Publications:
Shimizu H, Lee GS, Beedanagari SR, Collins MD. Altered localization of gene expression in both ectoderm and mesoderm is associated with a murine strain difference in retinoic acid-induced forelimb ectrodactyly. Birth Defects Res A Clin Mol Teratol. 2007; 79(6): 465-82.
Lee GS, Liao X, Cantor RM, Collins MD. Interactive effects of cadmium and all-trans-retinoic acid on the induction of forelimb ectrodactyly in C57BL/6 mice. Birth Defects Res A Clin Mol Teratol. 2006; 76(1): 19-28.
Lee GS, Cantor RM, Abnoosian A, Park E, Yamamoto ML, Hovland DN, Collins MD. A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11. Genetics. 2005; 170(1): 345-53.
Xia Y, Bian Q, Xu L, Collins MD, Chang HC, Song L, Liu J, Wang S, Wang X. Genotoxic effects on spermatozoa of carbaryl-exposed workers. Toxicol Sci. 2005; 85(1): 615-23.
Lee GS, Kochhar DM, Collins MD. Retinoid-induced limb malformations. Curr Pharm Des. 2004; 10(22): 2657-99.