The major focus of Dr. Sanjay Mallya’s research is to understand the molecular mechanisms of oral neoplastic development and progression. Specifically, he is studying the role of the cyclin D1 oncogene in this process. Cyclin D1, a key regulator of the G1-S phase of the cell cycle is deregulated in a vast majority of human oral cancers. Using transgenic animal models of oral premalignancy, he is studying the interaction between cyclin D1 deregulation and environmental factors in the development of oral squamous cell carcinoma, as well as the molecular and genetic events that occur during the multi-step progression of these neoplasms. His laboratory is also studying the role of the vitamin D receptor in regulation of oral keratinocyte proliferation and differentiation and its implications for oral carcinogenesis.
Selected Cancer-Related Publications:
Patel MM, Wilkey JF, Abdelsayed R, D'Silva NJ, Malchoff C, Mallya SM. Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 May;109(5):739-43. Epub 2010 Mar 25.
Wilkey JF, Buchberger G, Saucier K, Patel SM, Eisenberg E, Nakagawa H, Michaylira CZ, Rustgi AK, Mallya SM. Cyclin D1 overexpression increases susceptibility to 4-nitroquinoline-1-oxide-induced dysplasia and neoplasia in murine squamous oral epithelium. Mol Carcinog. 2009 Sep;48(9):853-61.
Dwivedi PP, Mallya S, Dongari-Bagtzoglou A. A novel immunocompetent murine model for Candida albicans-promoted oral epithelial dysplasia. Med Mycol. 2009 Mar;47(2):157-67. Epub 2008 Jun 10.
Mallya SM, Gallagher JJ, Wild YK, Kifor O, Costa-Guda J, Saucier K, Brown EM, Arnold A. Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism. Mol Endocrinol. 2005 Oct;19(10):2603-9. Epub 2005 May 31.
Mallya SM, Gallagher JJ, Arnold A. Analysis of microsatellite instability in sporadic parathyroid adenomas. J Clin Endocrinol Metab. 2003 Mar;88(3):1248-51.