Dr. Yanyuan Wu’s research has focused on identifying specific cellular and molecular markers for early detection, prevention and management of breast cancer, understanding the molecular pathology of breast cancer in underserved populations and engaging in target therapy. Her current research is to study the oncogenic role of AKT and the transcription factors Snail and Slug in HER2/neu overexpressing breast tumor.
Selected Cancer-Related Publications:
Wu Y, Alvarez M, Slamon DJ, Koeffler P, Vadgama JV. Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation. BMC Cancer. 2010 Feb 4;10:32.
Wu Y, Shang X, Sarkissyan M, Slamon D, Vadgama JV. FOXO1A is a target for HER2-overexpressing breast tumors. Cancer Res. 2010 Jul 1;70(13):5475-85. Epub 2010 Jun 15.
Wu Y, Mohamed H, Chillar R, Ali I, Clayton S, Slamon D, Vadgama JV. Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer. Breast Cancer Res. 2008;10(1):R3. Epub 2008 Jan 10.
Wu Y, Shen D, Chen Z, Clayton S, Vadgama JV. Taxol induced apoptosis regulates amino acid transport in breast cancer cells. Apoptosis. 2007 Mar;12(3):593-612. Epub 2006 Dec 29.
Wu Y, Khan H, Chillar R, Vadgama JV. Prognostic value of plasma HER-2/neu in African American and Hispanic women with breast cancer. Int J Oncol. 1999 Jun;14(6):1021-37.