Dr. Gustavo Miranda-Carboni's reasearch interests are on modeling human breast cancer using mouse models of the Wnt/beta-catenin signaling pathway. His translation model is for a subset of human breast cancers known as Triple-Negative which afflicts African-American women three times higher than other ethnic groups. This type of breast cancer is highly aggressive, lacks any known therapeutics and afflicts pre-menopausal women at ~33 percent of the time upon diagnosis.
Selected Cancer-Related Publications:
Krum SA, la Rosa Dalugdugan E, Miranda-Carboni GA, Lane TF. BRCA1 Forms a Functional Complex with gamma-H2AX as a Late Response to Genotoxic Stress. J Nucleic Acids. 2010 Sep 27;2010. pii: 801594.
Krum SA, Chang J, Miranda-Carboni G, Wang CY. Novel functions for NFKappaB: inhibition of bone formation. Nat Rev Rheumatol. 2010 Oct;6(10):607-11. Epub 2010 Aug 10.
Stevens JR, Miranda-Carboni GA, Singer MA, Brugger SM, Lyons KM, Lane TF. Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res. 2010 Oct;25(10):2138-47.
Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008 Nov 15;22(22):3121-34.
Jones KA, Kemp CR. Wnt-induced proteolytic targeting. Genes Dev. 2008 Nov 15;22(22):3077-81.