Estrogen plays a biological role in the mammary gland, ovaries, brain, heart and bone, among other tissues. The molecular mechanism of the tissue-specificity of estrogen action, however, is not well-studied. Dr. Susan Krum-Miranda’s laboratory aims to understand gene regulation by estrogen and to understand why there are different biological effects of estrogen in different tissues, which is of key importance for anti-estrogen and estrogen deprivation therapies for patients with breast cancer. Patients with estrogen receptor (ER) positive breast cancer are treated with selective estrogen receptor modulators (SERMs) or aromatase inhibitors to prevent the proliferation of breast cancer. However, estrogen also has necessary roles in other tissues. It is imperative to understand the biology of estrogen, environmental estrogens and breast cancer treatments in both the breast and in these other organs.
Selected Cancer-Related Publications:
Krum SA, la Rosa Dalugdugan E, Miranda-Carboni GA, Lane TF. BRCA1 Forms a Functional Complex with gamma-H2AX as a Late Response to Genotoxic Stress. J Nucleic Acids. 2010 Sep 27;2010. pii: 801594.
Krum SA, Miranda-Carboni GA, Lupien M, Eeckhoute J, Carroll JS, Brown M. Unique ERalpha cistromes control cell type-specific gene regulation. Mol Endocrinol. 2008 Nov;22(11):2393-406. Epub 2008 Sep 25.
Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS, Brown M. Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer. Cancer Res. 2007 Jul 1;67(13):6477-83.
Krum SA, Womack JE, Lane TF. Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. Oncogene. 2003 Sep 4;22(38):6032-44.
Krum SA, Miranda GA, Lin C, Lane TF. BRCA1 associates with processive RNA polymerase II. J Biol Chem. 2003 Dec 26;278(52):52012-20. Epub 2003 Sep 23.