Dr. Jesus Araujo's research interests are focused on dissecting mechanisms, molecular pathways and gene-environment interactions of relevance in the induction of cardiopulmonary effects by air pollutants. His Environmental Cardiology and Vascular Biology Laboratory is studying how air particulate matter (PM) promotes atherosclerosis and ischemic heart disease, likely via the promotion of systemic prooxidative and proinflammatory effects that may occur as a consequence of similar effects in the Lungs. Dr. Araujo is also interested to determine how PM-induced pro-oxidative and pro-inflammatory effects in the lungs may lead to DNA damage and pro-oncogenic effects, which appear to be similar to effects caused by passive cigarette smoking.
Selected Cancer-Related Publications:
Hickey MJ, Malone CC, Erickson KE, Gomez GG, Young EL, Liau LM, Prins RM, Kruse CA. Implementing preclinical study findings to protocol design: translational studies with alloreactive CTL for gliomas. Am J Transl Res. 2012;4(1):114-26. Epub 2012 Jan 10.
Ma W, Chen M, McElroy M, Zhang Y, Ozkan C, Bouvet M, Kruse CA, Grotjahn D, Ichim T, Minev B. PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses. Intl. J. Nanomed. 2012 7, 1475-1487.
Hickey MJ, Malone CC, Erickson KL, Jadus MR, Prins RM, Liau LM, Kruse CA. Cellular and vaccine therapeutic approaches for gliomas. J Transl Med. 2010 Oct 14;8:100.
Hickey MJ, Malone CC, Erickson KL, Jadus MR, Prins RM, Liau LM, Kruse CA.Cellular and vaccine therapeutic approaches for gliomas. J Transl Med. 2010 Oct 14;8:100.
Gomez GG, Hickey MJ, Tritz R, Kruse CA. Immunoresistant human glioma cell clones selected with alloreactive cytotoxic T lymphocytes: downregulation of multiple proapoptotic factors. Gene Ther Mol Biol. 2008 Jun;12(1):101-110.