Dr. Huan Meng’s research mainly focuses on nanomedicine and nanobiology. Meng plays a key role in the interdisciplinary Division of NanoMedicine at UCLA, including the safe design of a nanoparticle-based platform for anticancer drug and therapeutic siRNA delivery in cancer cells and intact animals. He is currently developing a list of particle design features that could successfully improve the utility of the multifunctional mesoporous silica nanoparticle platform that is being used for cargo molecules delivery, by controlling pore opening with variables including nanovalves, surface ligation modification and surface charge variation, and size and aspect ratio tuning. Meng also works for the Center for Environmental Implications of Nanotechnology (UC CEIN) at UCLA, where he and his colleagues study the safety of engineered nanomaterials, including the establishment of the link between biological outcomes and material properties that could lead to bio-compatible or bio-hazardous interactions in mammalian cells and animals.
Selected Cancer-Related Publications:
Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, Pokhrel S, Lin S, Wang X, Liao YP, Wang M, Li L, Rallo R, Damoiseaux R, Telesca D, Mädler L, Cohen Y, Zink JI, Nel AE. Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano. 2012 May 22;6(5):4349-68. Epub 2012 Apr 24
Meng H, Xue M, Xia T, Ji Z, Tarn DY, Zink JI, Nel AE. Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model. ACS Nano. 2011 May 24;5(5):4131-44. Epub 2011 Apr 27
Meng H, Liong M, Xia T, Li Z, Ji Z, Zink JI, Nel AE. Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano. 2010 Aug 24;4(8):4539-50.
Meng H, Xue M, Xia T, Zhao YL, Tamanoi F, Stoddart JF, Zink JI, Nel AE. Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. J Am Chem Soc. 2010 Sep 15;132(36):12690-7.
Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, Zink JI, Nel AE. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano. 2009 Oct 27;3(10):3273-86.