James K. Gimzewski, Ph.D., Ph.D. h.c., D.Sc. h.c., F.R.S., F.R.Eng., F.Io.N., F.W.I.F., F.Inst.P., Cphys
Affiliation(s):
Distinguished Professor, Department of Chemistry and Biochemistry
Faculty Director, California NanoSystems Institute (CNSI) Nano and Pico Characterization Core Facility
Scientific Director, UCLA Art/Sci Center
Principal Investigator and Satellites Co-Director, World Premier International (WPI) Center for Materials Nanoarchitectonics (MANA)
Member, JCCC Cancer Nanotechnology Program Area
Scientific Interest(s):
Dr. James Gimzewski’s current research activities include correlation of nanomechanics of cells and single molecule force spectoscropy of cells and tissue with cancer using atomic force microscopy/ spectroscopy, STED, SEM, and optical interformerty. He also studies RNA single molecule profiles with AFM and neuronal protein binding with actin.
Selected Cancer-Related Publications:
Sharma S, Santiskulvong C, Bentolila LA, Rao J, Dorigo O, Gimzewski JK. Correlative nanomechanical profiling with super-resolution F-actin imaging reveals novel insights into mechanisms of cisplatin resistance in ovarian cancer cells. Nanomedicine. 2011 Oct 22. [Epub ahead of print]
Cross SE, Jin YS, Lu QY, Rao J, Gimzewski JK. Green tea extract selectively targets nanomechanics of live metastatic cancer cells. Nanotechnology. 2011 May 27;22(21):215101. Epub 2011 Mar 30.
Ghoneum M, Ghoneum A, Tolentino L, Gimzewski J. Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material. In Vivo. 2010 Mar-Apr;24(2):141-6.
Sharma S, Rasool HI, Palanisamy V, Mathisen C, Schmidt M, Wong DT, Gimzewski JK. Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano. 2010 Apr 27;4(4):1921-6.
Reed J, Hsueh C, Mishra B, Gimzewski JK. Atomic force microscope observation of branching in single transcript molecules derived from human cardiac muscle. Nanotechnology. 2008 Sep 24;19(38):384021. Epub 2008 Aug 12.