Dr. Sanjai Sharma is a physician-scientist with an interest in chronic lymphocytic leukemia (CLL). His lab focuses on identification analysis of genetic abnormalities in CLL, role of aberrant splicing in tumorigenesis and genome wide analysis of cancer cells with high throughput sequencing.
Selected Cancer-Related Publications:
Sharma S, Liao W, Zhou X, Wong DT, Lichtenstein A. Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells. Mol Cancer Ther. 2011 Sep;10(9):1751-9. Epub 2011 Jul 15.
Sharma S, Lichtenstein A. Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells. Blood. 2009 Nov 5;114(19):4179-85. Epub 2009 Sep 10.
Sharma S, Lichtenstein A. Dexamethasone-induced apoptotic mechanisms in myeloma cells investigated by analysis of mutant glucocorticoid receptors. Blood. 2008 Aug 15;112(4):1338-45. Epub 2008 May 30.
Sharma S, Nemeth E, Chen YH, Goodnough J, Huston A, Roodman GD, Ganz T, Lichtenstein A. Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res. 2008 Jun 1;14(11):3262-7.
Yan H, Frost P, Shi Y, Hoang B, Sharma S, Fisher M, Gera J, Lichtenstein A. Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis. Cancer Res. 2006 Feb 15;66(4):2305-13.