Dr. Dean Ho's team is currently developing nanodiamond-based platforms for targeted chemotherapeutic delivery and nanodiamond-enhanced magnetic resonance imaging (MRI) agents. His team has demonstrated marked enhancements to small molecule efficacy and safety in multiple drug-resistant tumor models. This work was published as the cover article in Science Translational Medicine (March 2011). Ho's group and colleagues have also synthesized nanodiamond-gadolinium contrast agents that have resulted in a one order of magnitude increase in per-gadolinium relaxivity. This is among the highest ever reported values compared to clinical and nanoparticle agents. Nanodiamonds are also capable of mediating a one order of magnitude improvement to gene delivery efficacy with preserved safety, and triggered therapeutic protein release. In addition to nanodiamond-based drug delivery and imaging, Ho's team is also developing polymeric microfilm devices for localized release of multiple compounds.
Selected Cancer-Related Publications:
Mochalin VN, Shenderova O, Ho D, Gogotsi Y. The properties and applications of nanodiamonds. Nat Nanotechnol. 2011 Dec 18;7(1):11-23. doi: 10.1038/nnano.2011.209.
Zhang XQ, Lam R, Xu X, Chow EK, Kim HJ, Ho D. Multimodal nanodiamond drug delivery carriers for selective targeting, imaging, and enhanced chemotherapeutic efficacy. Adv Mater. 2011 Nov 2;23(41):4770-5. doi: 10.1002/adma.201102263. Epub 2011 Sep 20.
Chow EK, Zhang XQ, Chen M, Lam R, Robinson E, Huang H, Schaffer D, Osawa E, Goga A, Ho D. Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. Sci Transl Med. 2011 Mar 9;3(73):73ra21.
Zhang XQ, Chen M, Lam R, Xu X, Osawa E, Ho D. Polymer-functionalized nanodiamond platforms as vehicles for gene delivery. ACS Nano. 2009 Sep 22;3(9):2609-16.
Huang H, Pierstorff E, Osawa E, Ho D. Active nanodiamond hydrogels for chemotherapeutic delivery. Nano Lett. 2007 Nov;7(11):3305-14. Epub 2007 Oct 5.