The long-term goal of Dr. Yi Xing’s research is to elucidate how genomic and environmental variation of RNA regulatory networks impacts phenotypic traits and diseases. His group combines genomic, bioinformatic, molecular and network approaches to study mRNA processing and post-transcriptional gene regulation in mammalian cells. They develop novel computational and statistical methods for analysis of massive genome and transcriptome data. They integrate computational studies with high-throughput and experimental research to systematically investigate the variation and dynamics of RNA regulatory networks between species, within human populations and in response to developmental and disease signals.
Selected Cancer-Related Publications:
Zhao K, Lu ZX, Park JW, Zhou Q, Xing Y. GLiMMPS: Robust statistical model for regulatory variation of alternative splicing using RNA-Seq data. Genome Biol. 2013 Jul 22;14(7):R74. [Epub ahead of print]
Shen S, Park JW, Huang J, Dittmar KA, Lu ZX, Zhou Q, Carstens RP, Xing Y. MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data. Nucleic Acids Res. 2012 Apr;40(8):e61. doi: 10.1093/nar/gkr1291. Epub 2012 Jan 20.
Shen S, Lin L, Cai JJ, Jiang P, Kenkel EJ, Stroik MR, Sato S, Davidson BL, Xing Y. Widespread establishment and regulatory impact of Alu exons in human genes. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2837-42. doi: 10.1073/pnas.1012834108. Epub 2011 Jan 31.
Warzecha CC, Jiang P, Amirikian K, Dittmar KA, Lu H, Shen S, Guo W, Xing Y, Carstens RP. An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J. 2010 Oct 6;29(19):3286-300. doi: 10.1038/emboj.2010.195. Epub 2010 Aug 13.
Lin L, Shen S, Tye A, Cai JJ, Jiang P, Davidson BL, Xing Y. Diverse splicing patterns of exonized Alu elements in human tissues. PLoS Genet. 2008 Oct 17;4(10):e1000225. doi: 10.1371/journal.pgen.1000225.