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JCCC Member Directory

Saman Sadeghi, Ph.D.
Saman Sadeghi, Ph.D.

Affiliation(s):

Assistant Professor, Department of Molecular and Medical Pharmacology
Director, Biomedical Cyclotron Facility
Member, JCCC Cancer Molecular Imaging Program Area

Contact Information:

Phone:
(310) 825-3170
Email:

Scientific Interest(s):

Dr. Saman Sadeghi’s research team is working to improve radiofluorination and synthesis of existing position emission tomography (PET) tracers and develop new PET tracers that support accurate diagnosis and treatment management for cancer patients. Current projects include:
  • Development of more efficient synthetic pathways to label radiopharmaceutical molecules for cancer diagnostics
  • Miniaturized on chip analytical techniques for separation and identification of solvents and impurities associated with synthesis of common PET probes
  • Electrochemical regioselective radiofluorination of aromatic moieties
  • Development of automated electrochemical radiosynthesis platforms
  • Electrochemically assisted solvent exchange and automated flow-through synthesizers.
Sadeghi is the director of the Ahmanson Biomedical Cyclotron Facility (BMC) that produces a wide variety of clinical PET biomarkers and oversees the translation of successful research probes to the clinic.

Selected Cancer-Related Publications:

Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta L, Le TM, Lee JT, Darvish R, Gordin A, Wei L, Liao HI, Wilks M, Martin C, Sadeghi S, Murphy JM, Boulos N, Phelps ME, Faull KF, Herschman HR, Jung ME, Czernin J, Lavie A, Radu CG. Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med. 2014 Mar 10;211(3):473-86. doi: 10.1084/jem.20131738. Epub 2014 Feb 24.

Murphy JM, Armijo AL, Nomme J, Lee CH, Smith QA, Li Z, Campbell DO, Liao HI, Nathanson DA, Austin WR, Lee JT, Darvish R, Wei L, Wang J, Su Y, Damoiseaux R, Sadeghi S, Phelps ME, Herschman HR, Czernin J, Alexandrova AN, Jung ME, Lavie A, Radu CG. Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. J Med Chem. 2013 Sep 12;56(17):6696-708. doi: 10.1021/jm400457y. Epub 2013 Aug 15.

Sadeghi S, Liang V, Cheung S, Woo S, Wu C, Ly J, Deng Y, Eddings M, van Dam RM. Reusable electrochemical cell for rapid separation of [18F]fluoride from [18O]water for flow-through synthesis of 18F-labeled tracers. Appl Radiat Isot. 2013 May;75:85-94. doi: 10.1016/j.apradiso.2012.12.021. Epub 2013 Feb 13.

Sadeghi S, Ding H, Shah GJ, Chen S, Keng PY, Kim CJ, van Dam RM. On chip droplet characterization: a practical, high-sensitivity measurement of droplet impedance in digital microfluidics. Anal Chem. 2012 Feb 21;84(4):1915-23. doi: 10.1021/ac202715f. Epub 2012 Feb 1.

Keng PY, Chen S, Ding H, Sadeghi S, Shah GJ, Dooraghi A, Phelps ME, Satyamurthy N, Chatziioannou AF, Kim CJ, van Dam RM. Micro-chemical synthesis of molecular probes on an electronic microfluidic device. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):690-5. doi: 10.1073/pnas.1117566109. Epub 2011 Dec 30.