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JCCC Member Directory

John P. Chute, M.D.
John P. Chute, M.D.


Hematology/Oncology and bone marrow transplantation

General Information:



Professor, Department of Medicine, Hematology/Oncology and Radiation Oncology
Member, Eli and Edythe Broad Stem Cell Research Center
Member, Bone Marrow/Stem Cell Transplantation Program
Member, UCLA Clinical Translational Science Institute
Member, JCCC Cancer and Stem Cell Biology Program Area
Member, JCCC Signal Transduction and Therapeutics Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center


Hematology/Oncology, National Naval Medical Center/National Cancer Institute, 1993 - 1996
Internal Medicine, National Naval Medical Center, 1991 - 1993
Internal Medicine, National Naval Medical Center, 1990 - 1991
Medical Degree:
M.D., Georgetown University School of Medicine, 1990


Board Certification(s):
Medical Oncology, American Board of Internal Medicine, 1997, 2008
Hematology, American Board of Internal Medicine, 1996, 2007
Internal Medicine, American Board of Internal Medicine, 1993, 2004
Diplomate, National Board of Medical Examiners, 1991

Contact Information:

(310) 206-3037
(310) 206-4929 Lab

Practice Information:

Clinical Interest(s):
Bone marrow transplantation, acute/chronic leukemias, lymphomas, myeloma, non-malignant hematologic diseases

Scientific Interest(s):

Dr. John Chute’s research laboratory focuses on the discovery of novel mechanisms which regulate hematopoietic stem cell self-renewal, regeneration and malignant transformation and the role of the microenvironment in regulating these processes.

Selected Cancer-Related Publications:

Doan PL, Himburg HA, Helms K, Russell JL, Fixsen E, Quarmyne M, Harris JR, Deoliviera D, Sullivan JM, Chao NJ, Kirsch DG, Chute JP. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med. 2013 Mar;19(3):295-304. doi: 10.1038/nm.3070. Epub 2013 Feb 3.

Himburg HA, Harris JR, Ito T, Daher P, Russell JL, Quarmyne M, Doan PL, Helms K, Nakamura M, Fixsen E, Herradon G, Reya T, Chao NJ, Harroch S, Chute JP. Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche. Cell Rep. 2012 Oct 25;2(4):964-75. doi: 10.1016/j.celrep.2012.09.002. Epub 2012 Oct 19.

Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, Chao NJ, Chute JP. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med. 2010 Apr;16(4):475-82. doi: 10.1038/nm.2119. Epub 2010 Mar 21.

Salter AB, Meadows SK, Muramoto GG, Himburg H, Doan P, Daher P, Russell L, Chen B, Chao NJ, Chute JP. Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. Blood. 2009 Feb 26;113(9):2104-7. doi: 10.1182/blood-2008-06-162941. Epub 2009 Jan 13.

Chute JP, Muramoto GG, Whitesides J, Colvin M, Safi R, Chao NJ, McDonnell DP. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11707-12. Epub 2006 Jul 20.