Dr. Judith Gasson's research focuses on understanding the processes that regulate the formation of normal blood cells and how those processes are perturbed in blood cell cancers such as leukemias.
Cells of the blood differ greatly in form and function, yet they are all derived from a common pluripotent "stem" cell in the bone marrow. Gasson and her colleagues have adapted a murine embryonic stem cell system to express an inducible form of constitutively active Notch, under conditions that mimic the stem cell niche in vivo. Global gene expression profiling studies have confirmed the importance of the Wnt pathway in maintenance of the primitive phenotype of these cells. Current experiments are focused upon identification and characterization of the transcriptional networks that regulate and maintain these pathways.
Selected Cancer-Related Publications:
Ganapati U, Tan HT, Lynch M, Dolezal M, de Vos S, Gasson JC. Modeling Notch Signaling in Normal and Neoplastic Hematopoiesis: Global Gene Expression Profiling in Response to Activated Notch Expression. Stem Cells. 2007.
Yaron Y, MacAdara J, Lynch M, Hughes E, Gasson J. A structural analysis of the function of HOXB7 in hematopoiesis. J. Immunol. 166, 5058-5067, 2001.
Tan-Pertel HT, Walker L, Browning D, Weinmaster G, Gasson JC. Notch signaling enhances survival and differentiation of 32Dcl3 myeloblasts. J. Immunol 165, 4428-4436, 2000.
Walker L, Lynch M, Silverman S, Fraser J, Boulter J, Weinmaster G, Gasson JC. The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro. Stem Cells 17:162 171, 1999.
Gasson JC, Weisbart RH, Kaufman SE, Clark SC, Hewick RM, Wong GG, Golde DW. Purified human granulocyte-macrophage colony-stimulating factor: Direct action on neutrophils. Science 226:1339-1342, 1984.