UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Harold G. Martinson, Ph.D.

Affiliation(s):

Professor, Department of Chemistry and Biochemistry

Member, JCCC Gene Regulation Program Area

Contact Information:

Phone:	(310) 825-3767
Email:	hgm@chem.ucla.edu

Scientific Interest(s):

Dr. Harold Martinson's lab is interested in the mechanism by which the transcriptional machinery in metazoans is functionally coupled to the processing machineries responsible for splicing and 3'-end cleavage and polyadenylation.

Selected Cancer-Related Publications:

Tsao DC, Park NJ, Nag A, Martinson HG. Prolonged alpha-amanitin treatment of cells for studying mutated polymerases causes degradation of DSIF160 and other proteins. RNA. 2012 Feb;18(2):222-9. Epub 2011 Dec 22.

Martinson HG. An active role for splicing in 3'-end formation. Wiley Interdiscip Rev RNA. 2011 Jul-Aug;2(4):459-70. doi: 10.1002/wrna.68. Epub 2010 Dec 16.

Rigo F, Martinson HG. Functional coupling of last-intron splicing and 3'-end processing to transcription in vitro: the poly(A) signal couples to splicing before committing to cleavage. Mol Cell Biol. 2008 Jan;28(2):849-62. Epub 2007 Oct 29.

Nag A, Narsinh K, Martinson HG. The poly(a)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase. Nature Struct Mol Biol. 2007; 14:662-669.

Rigo F, Kazerouninia A, Nag A, Martinson HG. The RNA tether from the poly(A) signal to the polymerase mediates coupling of transcription to cleavage and polyadenylation. Mol Cell. 2005 Dec 9;20(5):733-45.