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Daniel Silverman, M.D., Ph.D.
Daniel Silverman, M.D., Ph.D.


Nuclear Medicine

General Information:



Head, Neuronuclear Imaging Section, Ahmanson Biological Imaging Division, UCLA Medical Center
Clinical Professor, Department of Molecular and Medical Pharmacology
Member, JCCC Cancer Molecular Imaging Program Area


Medicine/Nuclear Medicine, UCLA School of Medicine, 1994 - 1996
Internal Medicine, UCLA School of Medicine, 1993 - 1994
Internal Medicine, UCLA School of Medicine, 1992 - 1993
Medical Degree:
M.D., Ohio State University College of Medicine, 1992
Ph.D., Harvard University, 1987


Board Certification(s):
Nuclear Medicine, American Board of Nuclear Medicine, 1996
Internal Medicine, American Board of Internal Medicine, 1995

Contact Information:

(310) 825-4257

Scientific Interest(s):

The two major goals of Dr. Daniel Silverman's research program are to explore in the living human brain the interactions and neurologic bases of memory, mood and pain perception - with respect to both normal and disordered function (as occurs in dementia, depression and chronic pain syndromes) and to develop noninvasive methodologies with which to optimize management of breast and colorectal cancers.

These apparently disparate objectives are united through use of low-level radioactive biochemicals to characterize and map in the human body the distribution of processes having pressing relevance to patients seen in nuclear and internal medicine. Both lines of research involve extensive application of positron emission tomography (PET). With a focus ranging from molecular processes to human behaviors, research activities correspondingly span the "bench to bedside" spectrum from biochemical work in vitro to monitoring and impacting upon progress of patients in the Ahmanson Biological Imaging Clinic.

Selected Cancer-Related Publications:

Fueger BJ, Czernin J, Cloughesy T, Silverman DH, Geist CL, Walter MA, Schiepers C, Nghiemphu P, Lai A, Phelps ME, Chen W. Correlation of 6-18F-fluoro-L-dopa PET uptake with proliferation and tumor grade in newly diagnosed and recurrent gliomas. J Nucl Med. 2010 Oct;51(10):1532-8. Epub 2010 Sep 16.

Silverman DH, Geist CL, Kenna HA, Williams K, Wroolie T, Powers B, Brooks J, Rasgon NL. Differences in regional brain metabolism associated with specific formulations of hormone therapy in postmenopausal women at risk for AD. Psychoneuroendocrinology. 2011 May;36(4):502-13. Epub 2010 Sep 1.

Kesner AL, Lau VK, Speiser M, Hsueh WA, Agazaryan N, DeMarco JJ, Czernin J, Silverman DH. Time-course of effects of external beam radiation on [18F]FDG uptake in healthy tissue and bone marrow. J Appl Clin Med Phys. 2008 Jun 23;9(3):2747.

Kesner AL, Hsueh WA, Htet NL, Pio BS, Czernin J, Pegram MD, Phelps ME, Silverman DH. Biodistribution and predictive value of 18F-fluorocyclophosphamide in mice bearing human breast cancer xenografts. J Nucl Med. 2007 Dec;48(12):2021-7. Epub 2007 Nov 15.

Silverman DH, Dy CJ, Castellon SA, Lai J, Pio BS, Abraham L, Waddell K, Petersen L, Phelps ME, Ganz PA. Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5-10 years after chemotherapy. Breast Cancer Res Treat. 2007 Jul;103(3):303-11. Epub 2006 Sep 29.