UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Janet Sinsheimer, Ph.D.

Affiliation(s):

Professor, Department of Human Genetics, Department of Biomathematics, Department of Biostatistics

Member, JCCC Healthy and At-Risk Populations Program Area

Contact Information:

Phone:	(310) 825-8002
Email:	janet@mednet.ucla.edu

Scientific Interest(s):

Dr. Janet Sinsheimer's research is focused on developing mathematical models for evolution and gene mapping. Her research program involves the development and application of statistical methodology for mapping complex trait and disease genes. Most recently, she has been working on statistical methods for detecting disease genes acting through maternal-fetal genotype incompatibility. She has also developed methods for realistic inference of evolutionary relationships and applied these methods to HIV evolution. Her research in HIV evolution seeks to understand the mechanisms by which HIV evades the immune system.

Selected Cancer-Related Publications:

Sehl M, Zhou H, Sinsheimer JS, Lange KL.Extinction models for cancer stem cell therapy. Math Biosci. 2011 Dec;234(2):132-46. Epub 2011 Oct 6.

Zhou H, Sehl ME, Sinsheimer JS, Lange K. Association screening of common and rare genetic variants by penalized regression. Bioinformatics. 2010 Oct 1;26(19):2375-82. Epub 2010 Aug 6.

Sehl ME, Langer LR, Papp JC, Kwan L, Seldon JL, Arellano G, Reiss J, Reed EF, Dandekar S, Korin Y, Sinsheimer JS, Zhang ZF, Ganz PA. Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer. Clin Cancer Res. 2009 Mar 15;15(6):2192-203. Epub 2009 Mar 10.

Sehl ME, Sinsheimer JS, Zhou H, Lange KL. Differential destruction of stem cells: implications for targeted cancer stem cell therapy. Cancer Res. 2009 Dec 15;69(24):9481-9.

Lee YC, Morgenstern H, Greenland S, Tashkin DP, Papp J, Sinsheimer J, Cao W, Hashibe M, You NC, Mao JT, Cozen W, Mack TM, Zhang ZF. A Case-Control Study of the Association of the Polymorphisms and Haplotypes of DNA Ligase I with Lung and Upper-Aerodigestive-Track Cancer. Int J Cancer. 2008 122:1630-8.