The Notch pathway is a highly conserved, ubiquitous signaling system that regulates a wide variety of cellular processes from cell fate decisions to tissue patterning and morphogenesis. Given that almost all structures in the body plan require Notch signaling at some point in their development, it is not surprising that defects in components of the Notch signaling pathway have been found associated with certain inherited diseases and cancer. The research in Dr. Gerry Weinmaster's laboratory seeks to understand the molecular mechanisms by which Notch signaling is induced and regulated by using a combination of cellular and animal model systems.
Selected Cancer-Related Publications:
Miyamoto A, Lau R, Hein PW, Shipley JM, Weinmaster G. Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. J Biol Chem. 2006; 281(15): 10089-97.
Haritunians T, Chow T, De Lange RP, Nichols JT, Ghavimi D, Dorrani N, St Clair DM, Weinmaster G, Schanen C. Functional analysis of a recurrent missense mutation in Notch3 in CADASIL. J Neurol Neurosurg Psychiatry. 2005; 76(9): 1242-8.
Ladi E, Nichols JT, Ge W, Miyamoto A, Yao C, Yang LT, Boulter J, Sun YE, Kintner C, Weinmaster G. The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol. 2005; 170(6): 983-92.
Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S. Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. J Neurosci. 2003; 23(5): 1730-41.
Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI. Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures. Dev Neurosci. 2003; 25(2-4): 162-72.