Dr. Zuo-Feng Zhang's research focuses on the molecular epidemiology of cancers of the bladder, prostate, esophagus, stomach, head and neck and cervix. Other research interests include nutrition and cancer, epidemiology of second primary cancer, methodological issues in the use of tumor markers in cancer epidemiology and progression and survival of cancer.
Zhang's research group in the molecular epidemiology laboratories is currently working on mutations, methylations, polymorphisms or SNPs of tumor suppresser genes such as TP53 and p16, of Phases I and II genes such as GSTs, NATs and CYP450s, and of DNA repair genes such as XRCC1. They seek to evaluate the main effects of these genes on the risk of cancers and to assess potential gene-environment interactions.
Selected Cancer-Related Publications:
Chao C, Zhang ZF, Berthiller J, Boffetta P, Hashibe M. NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006; 15(5): 979-87.
Chuang SC, Hashibe M, Yu GP, Le AD, Cao W, Hurwitz EL, Rao JY, Neugut AI, Zhang ZF. Radiotherapy for primary thyroid cancer as a risk factor for second primary cancers. Cancer Lett. 2006; 238(1): 42-52.
Hashibe M, Ritz B, Le AD, Li G, Sankaranarayanan R, Zhang ZF. Radiotherapy for oral cancer as a risk factor for second primary cancers. Cancer Lett. 2005; 220(2): 185-95.
Hashibe M, Straif K, Tashkin DP, Morgenstern H, Greenland S, Zhang ZF. Epidemiologic review of marijuana use and cancer risk. Alcohol. 2005; 35(3): 265-75.
Cao W, Hashibe M, Rao JY, Morgenstern H, Zhang ZF. Comparison of methods for DNA extraction from paraffin-embedded tissues and buccal cells. Cancer Detect Prev. 2003; 27(5): 397-404.