Dr. Ohyun Kwon's research interest lies in the development of new methodologies for organic transformations, target-oriented synthesis of biologically important natural compounds and diversity oriented synthesis of natural product-like molecules. Molecules thus built will be employed in the investigation of biologically significant processes.
Selected Cancer-Related Publications:
Creech GS, Kwon O. Alcohol-assisted phosphine catalysis: one-step syntheses of dihydropyrones from aldehydes and allenoates. Org Lett. 2008 Feb 7;10(3):429-32. Epub 2008 Jan 4.
Watanabe M, Fiji HD, Guo L, Chan L, Kinderman SS, Slamon DJ, Kwon O, Tamanoi F. Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds. J Biol Chem. 2008 Apr 11;283(15):9571-9. Epub 2008 Jan 28.
Sriramurthy V, Barcan GA, Kwon O. Bisphosphine-catalyzed mixed double-Michael reactions: asymmetric synthesis of oxazolidines, thiazolidines, and pyrrolidines. J Am Chem Soc. 2007 Oct 31;129(43):12928-9. Epub 2007 Oct 9.
Tran YS, Kwon O. Phosphine-catalyzed [4 + 2] annulation: synthesis of cyclohexenes. J Am Chem Soc. 2007 Oct 24;129(42):12632-3. Epub 2007 Oct 3.
Castellano S, Fiji HD, Kinderman SS, Watanabe M, Leon P, Tamanoi F, Kwon O. Small-molecule inhibitors of protein geranylgeranyltransferase type I. J Am Chem Soc. 2007; 129(18): 5843-5.