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Shimon Weiss, Sc.D.
Shimon Weiss, Sc.D.


Professor, Department of Chemistry and Biochemistry
Member, JCCC Cancer Nanotechnology Program Area

Contact Information:

(310) 794-0093

Scientific Interest(s):

Dr. Shimon Weiss's research focuses on single molecule biophysics, particularly the application of single molecule spectroscopy: to biology and nanotechnology, dynamic structural biology, conformational dynamics of molecular machines, protein folding, protein-DNA and protein-protein interactions, single molecule enzymology, ultrahigh resolution & ultrahigh sensitivity fluorescence microscopy and spectroscopy and the physics and chemistry of mesoscopic (nano-scale) systems.

Selected Cancer-Related Publications:

Dertinger T, Colyer R, Vogel R, Heilemann M, Sauer M, Enderlein J, Weiss S. Superresolution optical fluctuation imaging (SOFI). Adv Exp Med Biol. 2012;733:17-21.

Kim S, Streets AM, Lin RR, Quake SR, Weiss S, Majumdar DS. High-throughput single-molecule optofluidic analysis. Nat Methods. 2011 Mar;8(3):242-5. Epub 2011 Feb 6

Dertinger T, Colyer R, Iyer G, Weiss S, Enderlein J. Fast, background-free, 3D super-resolution optical fluctuation imaging (SOFI). Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22287-92. Epub 2009 Dec 14

Bentolila LA, Weiss S. Single-step multicolor fluorescence in situ hybridization using semiconductor quantum dot-DNA conjugates. Cell Biochem Biophys. 2006; 45(1): 59-70.

Jager M, Nir E, Weiss S. Site-specific labeling of proteins for single-molecule FRET by combining chemical and enzymatic modification. Protein Sci. 2006; 15(3): 640-6.