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UCLA's Jonsson Comprehensive Cancer Center

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JCCC Member Directory

Amander T. Clark, Ph.D.
Amander T. Clark, Ph.D.

Affiliation(s):

Associate Professor, Department of Molecular, Cell, and Developmental Biology
Member, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Member, ACCESS Department - Molecular, Cell, and Developmental Biology
Member, JCCC Cancer and Stem Cell Biology Program Area

Contact Information:

Phone:
(310) 794-4201
Email:
clarka@ucla.edu

Scientific Interest(s):

Dr. Amander Clark is interested in characterizing molecular programs unique to stem cells. She discovered a locus of genes on human chromosome 12p13 that are specifically expressed in human embryonic stem cells, germ cells and cancer cells. However, the mechanism of these genes in regulating cell biology is almost completely unknown. Her research seeks to understand the molecular mechanisms by which these genes regulate cell biology and to determine the utility of these genes as tumor biomarkers or possibly cancer therapeutics.

Selected Cancer-Related Publications:

Conway AE, Lindgren A, Galic Z, Pyle AD, Wu H, Zack JA, Pelligrini M, Teitell MA, Clark A. A Pluripotency and Self-Renewal Program Controls the Expansion of Genetically Unstable Cancer Stem Cells in Pluripotent Stem Cell-Derived Tumors. Stem Cells. 2008 Oct 2. [Epub ahead of print]

Wu H, Kim KJ, Mehta K, Paxia S, Sundstrom A, Anantharaman T, Kuraishy AI, Doan T, Ghosh J, Pyle AD, Clark A, Lowry W, Fan G, Baxter T, Mishra B, Sun Y, Teitell MA. Copy number variant analysis of human embryonic stem cells. Stem Cells. 2008 Jun;26(6):1484-9. Epub 2008 Mar 27.

Lowry WE, Richter L, Yachechko R, Pyle AD, Tchieu J, Sridharan R, Clark AT, Plath K. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2883-8. Epub 2008 Feb 15.

Clark AT. The stem cell identity of testicular cancer. Stem Cell Rev. 2007 Jan;3(1):49-59.

Bostick M, Kim JK, Estève PO, Clark A, Pradhan S, Jacobsen SE. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science. 2007 Sep 21;317(5845):1760-4. Epub 2007 Aug 2.

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