UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Yi Sun, Ph.D.

Affiliation(s):

Assistant Professor, Department of Psychiatry and Biobehavioral Sciences, Department of Molecular and Medical Pharmacology

Associate Academic Director, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research

Member, ACCESS Department - Molecular and Medical Pharmacology, Neuroscience Graduate Program, Brain Research Institute

Member, JCCC Gene Regulation Program Area

Contact Information:

Phone:	(310) 825-9506
Email:	ysun@mednet.ucla.edu

Scientific Interest(s):

Dr. Yi Sun is interested in genetic and DNA methylation-related epigenetic mechanisms underlying neural stem cell proliferation and differentiation, and their relevance to glioblastoma and potential brain cancer stem cells. She is investigating the identity of brain cancer stem cells in her lab, studying intracellular signaling pathways that include JAK-STAT, Notch signaling, BMP-Smad and Wnt signaling pathways.

Selected Cancer-Related Publications:

Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE. Coupling of cell migration with neurogenesis by proneural bHLH factors. Proc Natl Acad Sci U S A. 2006; 103(5): 1319-24.

Krueger RC, Wu H, Zandian M, Danielpour M, Kabos P, Yu JS, Sun YE. Neural progenitors populate the cerebrospinal fluid of preterm patients with hydrocephalus. J Pediatr. 2006; 148(3): 337-340.

He F, Ge W, Martinowich K, Becker-Catania S, Coskun V, Zhu W, Wu H, Castro D, Guillemot F, Fan G, de Vellis J, Sun YE. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci. 2005; 8(5): 616-25.

Ladi E, Nichols JT, Ge W, Miyamoto A, Yao C, Yang LT, Boulter J, Sun YE, Kintner C, Weinmaster G. The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol. 2005; 170(6): 983-92.

Martin KC, Sun YE. To learn better, keep the HAT on. Neuron. 2004; 42(6): 879-81.