Dr. Arion Chatziioannou's research lab is developing technology specifically designed for in vivo molecular imaging. The focus of their research is around non-invasive techniques, like positron emission tomography (PET), x-ray micro computed tomography (microCAT), and optical imaging systems. In this process, they: design and simulate from detectors to complete imaging systems; construct detectors and complete prototype systems; and develop and implement linear and iterative data correction and image reconstruction algorithms as well as data analysis and visualization tools. They are also developing hardware and software solutions to complex computationally intensive problems like: iterative image reconstruction; deformable model image registration from data acquired by multiple imaging modalities; and high throughput screening. These tools have been used by biologists to transform in vitro mammalian biology into the setting of living animals.
Selected Cancer-Related Publications:
Vu NT, Yu ZT, Comin-Anduix B, Sondergaard JN, Silverman RW, Chang CY, Ribas A, Tseng HR, Chatziioannou AF. A beta-camera integrated with a microfluidic chip for radioassays based on real-time imaging of glycolysis in small cell populations. J Nucl Med. 2011 May;52(5):815-21.
Lu Y, Machado HB, Bao Q, Stout D, Herschman H, Chatziioannou AF. In vivo mouse bioluminescence tomography with radionuclide-based imaging validation. Mol Imaging Biol. 2011 Feb;13(1):53-8.
Virk MS, Alaee F, Petrigliano FA, Sugiyama O, Chatziioannou AF, Stout D, Dougall WC, Lieberman JR. Combined inhibition of the BMP pathway and the RANK-RANKL axis in a mixed lytic/blastic prostate cancer lesion. Bone. 2011 Mar 1;48(3):578-87. Epub 2010 Nov 10
Fang C, Wang Y, Vu NT, Lin WY, Hsieh YT, Rubbi L, Phelps ME, Muschen M, Kim YM, Chatziioannou AF, Tseng HR, Graeber TG. Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples. Cancer Res. 2010 Nov 1;70(21):8299-308. Epub 2010 Sep 13
Bao Q, Chatziioannou AF. Estimation of the minimum detectable activity of preclinical PET imaging systems with an analytical method. Med Phys. 2010 Nov;37(11):6070-83.