Dr. Arion Chatziioannou's research lab is developing technology specifically designed for in vivo molecular imaging. The focus of their research is around non-invasive techniques, like positron emission tomography (PET), x-ray micro computed tomography (microCAT), and optical imaging systems. In this process, they: design and simulate from detectors to complete imaging systems; construct detectors and complete prototype systems; and develop and implement linear and iterative data correction and image reconstruction algorithms as well as data analysis and visualization tools. They are also developing hardware and software solutions to complex computationally intensive problems like: iterative image reconstruction; deformable model image registration from data acquired by multiple imaging modalities; and high throughput screening. These tools have been used by biologists to transform in vitro mammalian biology into the setting of living animals.
Selected Cancer-Related Publications:
Deroose CM, De A, Loening AM, Chow PL, Ray P, Chatziioannou AF, Gambhir SS. Multimodality imaging of tumor xenografts and metastases in mice with combined small-animal PET, small-animal CT, and bioluminescence imaging. J Nucl Med. 2007; 48(2): 295-303.
Dogdas B, Stout D, Chatziioannou AF, Leahy RM. Digimouse: a 3D whole body mouse atlas from CT and cryosection data. Phys Med Biol. 2007; 52(3): 577-87.
Hsu WK, Feeley BT, Krenek L, Stout DB, Chatziioannou AF, Lieberman JR. The use of (18)F-fluoride and (18)F-FDG PET scans to assess fracture healing in a rat femur model. Eur J Nucl Med Mol Imaging. 2007.
Taschereau R, Chatziioannou AF. Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds. Med Phys. 2007; 34(3): 1026-36.
Taschereau R, Chow PL, Chatziioannou AF. Monte carlo simulations of dose from microCT imaging procedures in a realistic mouse phantom. Med Phys. 2006; 33(1): 216-24.