Dr. David Stout's research interests are in developing the tools, procedures and techniques necessary to conduct molecular imaging research using optical, positron emisson tomography (PET), computed tomography (CT) and autoradiography systems. These include chambers for keeping the subjects warm, anesthetized, in a reproducible position and for imaging in multiple systems. He also has interest and expertise in the design of preclinical imaging centers. Stout has designed the new imaging center in the California Nanosystems Institute and is currently working on the logistics of moving the imaging center that annually conducts over 14,000 experiments with minimal disruption to the 42 faculty members using the center.
Stout teaches molecular imaging courses to train new investigators how to design, conduct and analyze data from these experiments. With a background in radiochemistry production of imaging probes, Ph.D. research involving quantitative measurements using PET and over 18 years experience in the UCLA Molecular and Medical Pharmacology department, Stout enjoys helping investigators design their experiments, obtain the necessary regulatory approvals and learn how to get the best possible experimental results.
Selected Cancer-Related Publications:
Burton JB, Johnson M, Sato M, Koh SB, Mulholland DJ, Stout D, Chatziioannou AF, Phelps ME, Wu H, Wu L. Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer. Nat Med. 2008 Aug;14(8):882-8. Epub 2008 Jul 11.
Dogdas B, Stout D, Chatziioannou AF, Leahy RM. Digimouse: a 3D whole body mouse atlas from CT and cryosection data. Phys Med Biol. 2007; 52(3): 577-87.
Fueger BJ, Czernin J, Hildebrandt I, Tran C, Halpern BS, Stout D, Phelps ME, Weber WA. Impact of animal handling on the results of 18F-FDG PET studies in mice. J Nucl Med. 2006; 47(6): 999-1006.
Lee CC, Sui G, Elizarov A, Shu CJ, Shin YS, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR. Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics. Science. 2005; 310(5755): 1793-6.
Stout DB, Chatziioannou AF, Lawson TP, Silverman RW, Gambhir SS, Phelps ME. Small animal imaging center design: the facility at the UCLA Crump Institute for Molecular Imaging. Mol Imaging Biol. 2005; 7(6): 393-402.