Dr. Gautam Chaudhuri's research involves utilizing in vivo, in vitro and molecular biology techniques to study physiological and pharmacological problems. He is studying the role of sex steroids in the modulation of endothelial cell function as it relates to control of vascular tone and development of atherosclerosis. Chaudhuri is also exploring factors modulating vascular tone in feto-placental vessels and factors involved in growth of female genital cancer.
Chaudhuri is currently studying the mechanism by which Estradiol and nitric oxide modulate various physiological functions and the signal transduction pathways involved. His major focus is on the effects of estrogens on atherogenesis. He is also studying the signaling mechanisms responsible for cell proliferation and apoptosis by using breast cancer cell lines as the model system.
Selected Cancer-Related Publications:
Pervin S, Tran AH, Zekavati S, Fukuto JM, Singh R, Chaudhuri G. Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis. Cancer Res. 2008 Jun 15;68(12):4862-74.
Pervin S, Singh R, Chaudhuri G. Nitric oxide, N omega-hydroxy-L-arginine and breast cancer. Nitric Oxide. 2008 Sep;19(2):103-6. Epub 2008 Apr 24. Review.
Souter I, Huang A, Martinez-Maza O, Breen EC, Decherney AH, Chaudhuri G, Nathan L. Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles. Fertil Steril. 2009 May;91(5 Suppl):2012-9. Epub 2008 Sep 7.
Pervin S, Singh R, Hernandez E, Wu G, Chaudhuri G. Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res. 2007; 67(1): 289-99.
Hayashi T, Esaki T, Sumi D, Mukherjee T, Iguchi A, Chaudhuri G. Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism. Proc Natl Acad Sci U S A. 2006; 103(27): 10485-90.