UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Tatiana Segura, Ph.D.

Affiliation(s):

Assistant Professor, Department of Chemical and Biomolecular Engineering

Member, JCCC Cancer Nanotechnology Program Area

Contact Information:

Phone:	(310) 206-3980
Email:	tsegura@ucla.edu

Scientific Interest(s):

Dr. Tatiana Segura's laboratory designs and synthesizes biomaterials that have a control ECM in order to study cancer cell biology. They seek to use these materials for novel delivery strategies for DNA therapeutics that target cancer cells.

Selected Cancer-Related Publications:

Adelöw C, Segura T, Hubbell JA, Frey P. The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype. Biomaterials. 2008 Jan;29(3):314-26. Epub 2007 Oct 22.

Segura T, Hubbell JA. Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery. Bioconjug Chem. 2007 May-Jun;18(3):736-45. Epub 2007 Mar 15.

Segura T, Schmokel H, Hubbell JA. RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats. J Surg Res. 2007 Aug;141(2):162-70. Epub 2007 Jun 11.

Segura T, Chung PH, Shea LD. DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach. Biomaterials. 2005 May;26(13):1575-84.

Segura T, Shea LD. Surface-tethered DNA complexes for enhanced gene delivery. Bioconjug Chem. 2002 May-Jun;13(3):621-9.