UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Yousang Gwack, Ph.D.

Affiliation(s):

Assistant Professor, Department of Physiology

Member, JCCC Signal Transduction and Therapeutics Program Area

Contact Information:

Phone:	(310) 794-2003
Email:	ygwack@mednet.ucla.edu

Scientific Interest(s):

Ca(2+) signaling pathways are universally present and regulate processes ranging from cell differentiation to cell death or proliferation. Dr. Yousang Gwack's long-term research goal is to understand the physiological role of the calcium release-activated calcium (CRAC) channels at an organism level.

Selected Cancer-Related Publications:

Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug;42(2):145-56. Epub 2007 Jun 18.

Gwack Y, Srikanth S, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 1;282(22):16232-43. Epub 2007 Feb 9.

Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11;441(7090):179-85. Epub 2006 Apr 2.

Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature. 2006 Jun 1;441(7093):646-50. Epub 2006 Mar 1.

Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG. Orai1 is an essential pore subunit of the CRAC channel. Nature. 2006 Sep 14;443(7108):230-3. Epub 2006 Aug 20.