The long term goals of Dr. Yi Tang's research program are to understand and engineer the biosynthetic machineries of microorganisms towards the production of important therapeutic compounds, including those that are anticancer and antimetastasis. Tang aims to gain fundamental understanding of the genetics and biochemistry of natural product metabolic pathways. Equipped with this knowledge, he seeks to reprogram these complex pathways towards tailored synthesis of new bioactive compounds.
Selected Cancer-Related Publications:
Zhou H, Zhan J, Watanabe K, Xie X, Tang Y. A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6249-54. Epub 2008 Apr 21.
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J. Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. J Am Chem Soc. 2008 May 14;130(19):6068-9. Epub 2008 Apr 19.
Xie X, Watanabe K, Wojcicki WA, Wang CC, Tang Y. Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem Biol. 2006 Nov;13(11):1161-9.
Khosla C, Tang Y. Chemistry. A new route to designer antibiotics.Science. 2005 Apr 15;308(5720):367-8.
Tang Y, Lee TS, Khosla C. Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases.PLoS Biol. 2004 Feb;2(2):E31. Epub 2004 Feb 17.