Dr. Shehnaz Hussain’s research is focused on the molecular epidemiology of cancer, particularly those cancers with infectious etiologies. The main objective of her research is to identify molecular markers, particularly those related to immune function, which alone or together with infections, environmental exposures or lifestyle factors, influence one’s risk of developing cancer. Current projects include 1) cytokine gene polymorphisms and cervical and vulvar cancer, 2) genetic epidemiology of familial breast cancer, and 3) genetic susceptibility and biomarkers in non-Hodgkin’s lymphoma.
Selected Cancer-Related Publications:
Hussain SK, Sundquist J, Hemminki K. The effect of having an affected parent or sibling on invasive and in situ skin cancer risk in Sweden. J Invest Dermatol. 2009 Sep;129(9):2142-7. Epub 2009 Feb 26.
Hussain SK, Sundquist J, Hemminki K. Familial clustering of cancer at human papillomavirus-associated sites according to the Swedish family-cancer database. Int J Cancer. 2008 Apr 15;122(8):1873-8.
Hussain SK, Sequerra R, Bertucci C, Hastings NC, Rieder M, Schwartz SM. Sequence variation in the human transcription factor gene POU5F1. BMC Genet. 2008 Feb 6;9:15.
Hussain SK, Madeleine MM, Johnson LG, Du Q, Malkki M, Wilkerson HW, Farin FM, Carter JJ, Galloway DA, Daling JR, Petersdorf EW, Schwartz SM. Cervical and vulvar cancer risk in relation to joint effects of cigarette smoking and genetic variation in interleukin 2. Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1790-9.
Park SL, Chang SC, Cai L, Cordon-Cardo C, Ding BG, Greenland S, Hussain SK, Jiang Q, Liu S, Lu ML, Mao JT, Morgenstern H, Mu LN, Ng LJ, Pantuck A, Rao J, Reuter VE, Tashkin DP, You NC, Yu CQ, Yu SZ, Zhao JK, Belldegrun A, Zhang ZF. Associations between variants of the 8q24 chromosome and nine smoking related cancer sites. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3193-202.