Dr. Grace Xiao's group is interested in the regulation of gene expression at the RNA level via the process of pre-mRNA splicing and other post-transcriptional (or co-transcriptional) mechanisms. They are investigating how different sequence motifs and trans-acting regulatory RNA or proteins exert concerted regulation to gene expression and how such regulation is disrupted in disease processes. Their work makes use of high-throughput sequencing and microarray expression technologies and approaches in molecular biology and bioinformatics.
Selected Cancer-Related Publications:
Bahn JH, Lee JH, Li G, Greer C, Peng G, Xiao X, Lee JH. Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res. 2012 Jan;22(1):142-50. Epub 2011 Sep 29
Gomez G, Lee JH, Veldman MB, Lu J, Xiao X, Lin S. Identification of vascular and hematopoietic genes downstream of etsrp by deep sequencing in zebrafish. PLoS One. 2012 Mar 16;7(3):e31658.
Li G, Bahn JH, Lee JH, Peng G, Chen Z, Nelson SF, Xiao X. Identification of allele-specific alternative mRNA processing via transcriptome sequencing. Nucleic Acids Res. 2012 Jul;40(13):e104. Epub 2012 Mar 29
Xiao X, Lee JH. Systems analysis of alternative splicing and its regulation. Wiley Interdiscip Rev Syst Biol Med. 2010 Sep-Oct;2(5):550-65.
Xiao X, Wang Z, Jang M, Nutiu R, Wang ET, Burge CB. Splice site strength-dependent activity and genetic buffering by poly-G runs. Nat Struct Mol Biol. 2009 Oct;16(10):1094-100. Epub 2009 Sep 13.