Dr. Gustavo Miranda-Carboni's reasearch interests are on modeling human breast cancer using mouse models of the Wnt/beta-catenin signaling pathway. His translation model is for a subset of human breast cancers known as Triple-Negative which afflicts African-American women three times higher than other ethnic groups. This type of breast cancer is highly aggressive, lacks any known therapeutics and afflicts pre-menopausal women at ~33 percent of the time upon diagnosis.
Selected Cancer-Related Publications:
Wend P, Wend K, Krum SA, Miranda-Carboni GA. The role of WNT10B in physiology and disease. Acta Physiol (Oxf). 2012 Jan;204(1):34-51. Epub 2011 May 7
Miranda-Carboni GA, Guemes M, Bailey S, Anaya E, Corselli M, Peault B, Krum SA. GATA4 regulates estrogen receptor-alpha-mediated osteoblast transcription. Mol Endocrinol. 2011 Jul;25(7):1126-36. Epub 2011 May 12
Krum SA, la Rosa Dalugdugan E, Miranda-Carboni GA, Lane TF. BRCA1 Forms a Functional Complex with ?-H2AX as a Late Response to Genotoxic Stress. J Nucleic Acids. 2010 Sep 27;2010.
Stevens JR, Miranda-Carboni GA, Singer MA, Brugger SM, Lyons KM, Lane TF. Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res. 2010 Oct;25(10):2138-47.
Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008 Nov 15;22(22):3121-34.