Dr. Yi-Ling Lin’s research focuses on transcription regulation during osteoclast differentiation. She is currently studying the relationship between Mitf, a helix-loop-helix lucine zipper transcription factor, and three other transcription factors, c-Fos, NF-kappaB and NFATc1, during RANKL signaling. Her goal is to develop therapeutic strategies to inhibit osteoclast activity for osteolytic diseases such as periodontitis and cancer bone metastasis.
Selected Cancer-Related Publications:
Basile JR, Lin YL. A salivary gland adenocarcinoma mimicking a microcystic adnexal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Apr;109(4):e28-33.
McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. 2002 Jun 14;109(6):707-18.
Ding HF, Lin YL, McGill G, Juo P, Zhu H, Blenis J, Yuan J, Fisher DE. Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. J Biol Chem. 2000 Dec 8;275(49):38905-11.
Lin YL, Shivji MK, Chen C, Kolodner R, Wood RD, Dutta A. The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair. J Biol Chem. 1998 Jan 16;273(3):1453-61.
Lin YL, Chen C, Keshav KF, Winchester E, Dutta A. Dissection of functional domains of the human DNA replication protein complex replication protein A. J Biol Chem. 1996 Jul 19;271(29):17190-8.