Studying the signaling pathways that promote invasion and metastasis in lung cancer is currently the focus of Dr. Fred Mortazavi's research. For example, as part of the adherens junction, p120-catenin (p120ctn) plays an important role in the stability of cell-cell adhesions and downregulation of the p120-catenin is reported in a large proportion (60-80%) of non-small cell lung cancer (NSCLC) cases. Mortazavi and others reported that p120-catenin is transcriptionally downregulated in NSCLC and identified two signaling pathways that mediate p120-catenin repression. Identifying the prometastatic signaling events in cancer cells could pave the way for the future interventions in order to stop the metastatic process.
Selected Cancer-Related Publications:
Mortazavi F, Dubinett S, Rettig M. c-Crk proto-oncogene contributes to transcriptional repression of p120-catenin in non-small cell lung cancer cells. Clin Exp Metastasis. 2011 Apr;28(4):391-404. Epub 2011 Feb 20.
Mortazavi F, An J, Dubinett S, Rettig M. p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells. Mol Cancer Res. 2010 May;8(5):762-74. Epub 2010 May 11.