Dr. Hailiang Hu’s research interest is to study the role of microRNAs in the DNA damage response for breast cancer and brain tumors. In particular, his laboratory focuses on the functions of ATM-related microRNAs in cell cycle checkpoints, DNA repair and DNA damage-induced apoptosis. Furthermore, they use breast cancer stem/initiating cells as a model to study the role of these microRNAs in radio/chemo-sensitivity, which might provide new therapeutic targets for radioresistant/chemoresistant cancers. Hu’s lab is also interested in developing small molecule readthrough compounds with Ataxia-telangiectasia iPSCs as models for treating human genetic diseases such as Ataxia-telangiectasia.
Selected Cancer-Related Publications:
Hu H, Gatti RA. MicroRNAs: new players in the DNA damage response. J Mol Cell Biol. 2011 Jun;3(3):151-8. Epub 2010 Dec 23.
Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1506-11. Epub 2010 Jan 4.
Du L, Damoiseaux R, Nahas S, Gao K, Hu H, Pollard JM, Goldstine J, Jung ME, Henning SM, Bertoni C, Gatti RA. Nonaminoglycoside compounds induce readthrough of nonsense mutations. J Exp Med. 2009 Sep 28;206(10):2285-97. Epub 2009 Sep 21.
Hu H, Milstein M, Bliss JM, Thai M, Malhotra G, Huynh LC, Colicelli J. Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration. Mol Cell Biol. 2008 Mar;28(5):1573-83. Epub 2007 Dec 26.
Hu H, Bliss JM, Wang Y, Colicelli J. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol. 2005 May 10;15(9):815-23.