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Francis Charles Brunicardi, M.D., F.A.C.S.
Francis Charles Brunicardi, M.D., F.A.C.S.


General surgery

General Information:



Professor and Chief, Department of Surgery, General Surgery
Member, JCCC Signal Transduction and Therapeutics Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center
UCLA Medical Center, Santa Monica


Surgery, SUNY Downstate Medical Center College of Medicine, 1983 - 1986
Surgery, SUNY Downstate Medical Center College of Medicine, 1986 - 1989
Surgery, SUNY Downstate Medical Center College of Medicine, 1982 - 1983
Surgery, UCSF/Mount Zion Medical Center, 1981 - 1982
Medical Degree:
M.D., UMDNJ New Jersey Medical School, 1980


Board Certification(s):
Surgery, American Board of Surgery, 1990, 1998, 2009

Contact Information:

(310) 562-1635

Practice Information:

Clinical Interest(s):
General surgery
Gastrointestinal cancers
Neuroendocrine tumors

Scientific Interest(s):

Dr. Charles Brunicardi's research interests are in pancreas cancer, RNAi therapy for cancer, gene therapy for cancer, islet physiology and personalized medicine.

Selected Cancer-Related Publications:

Zhou G, Liu SH, Shahi KM, Wang H, Duan X, Lin X, Feng XH, Li M, Fisher WE, Demayo FJ, Dawson D, Brunicardi FC. Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5. Mol Endocrinol. 2012 Jul;26(7):1225-34. Epub 2012 Jun 5

Liu SH, Smyth-Templeton N, Davis AR, Davis EA, Ballian N, Li M, Liu H, Fisher W, Brunicardi FC. Multiple treatment cycles of liposome-encapsulated adenoviral RIP-TK gene therapy effectively ablate human pancreatic cancer cells in SCID mice. Surgery. 2011 Apr;149(4):484-95. Epub 2011 Feb 5

Nemunaitis J, Rao DD, Liu SH, Brunicardi FC. Personalized cancer approach: using RNA interference technology. World J Surg. 2011 Aug;35(8):1700-14.

Zhou G, Gingras MC, Liu SH, Sanchez R, Edwards D, Dawson D, Christensen K, Paganelli G, Gibbs R, Fisher W, Brunicardi FC. SSTR5 P335L monoclonal antibody differentiates pancreatic neuroendocrine neuroplasms with different SSTR5 genotypes. Surgery. 2011 Dec;150(6):1136-42.

Liu S, Ballian N, Belaguli NS, Patel S, Li M, Templeton NS, Gingras MC, Gibbs R, Fisher W, Brunicardi FC. PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer. Pancreas. 2008 Aug;37(2):210-20.