Dr. Edward De Robertis' research focuses on the molecular biology of vertebrate gastrulation. During early vertebrate development, coordinated movements of groups of cells lead to the formation of the three germ layers: the ectoderm, the mesoderm and the endoderm. This process is called gastrulation, and by the end of it the main regions of the embryo - head, trunk and tail - become determined. De Robertis' work is aimed at identifying the genetic mechanisms that direct the formation of the body plan in frog or mouse embryos. De Robertis studies the BMP and Wnt signaling pathways and how they are integrated in the embryo.
Selected Cancer-Related Publications:
Dobrowolski R, De Robertis EM. Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles. Nat Rev Mol Cell Biol. 2011 Nov 23;13(1):53-60. doi: 10.1038/nrm3244.
Eivers E, Demagny H, Choi RH, De Robertis EM. Phosphorylation of Mad controls competition between wingless and BMP signaling. Sci Signal. 2011 Oct 11;4(194):ra68. doi: 10.1126/scisignal.2002034.
Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, Gumper I, Sabatini DD, De Robertis EM. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell. 2010 Dec 23;143(7):1136-48.
Lee HX, Mendes FA, Plouhinec JL, De Robertis EM. Enzymatic regulation of pattern: BMP4 binds CUB domains of Tolloids and inhibits proteinase activity. Genes Dev. 2009 Nov 1;23(21):2551-62.
Fuentealba LC, Eivers E, Ikeda A, Hurtado C, Kuroda H, Pera EM, De Robertis EM. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell. 2007 Nov 30;131(5):980-93.