James K. Gimzewski, Ph.D., Ph.D. h.c., D.Sc. h.c., F.R.S., F.R.Eng., F.Io.N., F.W.I.F., F.Inst.P., Cphys
Distinguished Professor, Department of Chemistry and Biochemistry
Faculty Director, California NanoSystems Institute (CNSI) Nano and Pico Characterization Core Facility
Scientific Director, UCLA Art/Sci Center
Principal Investigator and Satellites Co-Director, World Premier International (WPI) Center for Materials Nanoarchitectonics (MANA)
Member, JCCC Cancer Nanotechnology Program Area
Dr. James Gimzewski’s current research activities include correlation of nanomechanics of cells and single molecule force spectoscropy of cells and tissue with cancer using atomic force microscopy/ spectroscopy, STED, SEM, and optical interformerty. He also studies RNA single molecule profiles with AFM and neuronal protein binding with actin.
Selected Cancer-Related Publications:
Sharma S, Santiskulvong C, Bentolila LA, Rao J, Dorigo O, Gimzewski JK. Correlative nanomechanical profiling with super-resolution F-actin imaging reveals novel insights into mechanisms of cisplatin resistance in ovarian cancer cells. Nanomedicine. 2011 Oct 22. [Epub ahead of print]
Cross SE, Jin YS, Lu QY, Rao J, Gimzewski JK. Green tea extract selectively targets nanomechanics of live metastatic cancer cells. Nanotechnology. 2011 May 27;22(21):215101. Epub 2011 Mar 30.
Ghoneum M, Ghoneum A, Tolentino L, Gimzewski J. Modulation of aged murine T lymphocytes in vivo by DPV576-C, a nanodiamond- and nanoplatinum-coated material. In Vivo. 2010 Mar-Apr;24(2):141-6.
Sharma S, Rasool HI, Palanisamy V, Mathisen C, Schmidt M, Wong DT, Gimzewski JK. Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano. 2010 Apr 27;4(4):1921-6.
Reed J, Hsueh C, Mishra B, Gimzewski JK. Atomic force microscope observation of branching in single transcript molecules derived from human cardiac muscle. Nanotechnology. 2008 Sep 24;19(38):384021. Epub 2008 Aug 12.