James K. Gimzewski, Ph.D., Ph.D. h.c., D.Sc. h.c., F.R.S., F.R.Eng., F.Io.N., F.W.I.F., F.Inst.P., Cphys
Distinguished Professor, Department of Chemistry and Biochemistry
Faculty Director, California NanoSystems Institute (CNSI) Nano and Pico Characterization Core Facility
Scientific Director, UCLA Art/Sci Center
Principal Investigator and Satellites Co-Director, World Premier International (WPI) Center for Materials Nanoarchitectonics (MANA)
Member, JCCC Cancer Nanotechnology Program Area
Dr. James Gimzewski’s current research activities include correlation of nanomechanics of cells and single molecule force spectoscropy of cells and tissue with cancer using atomic force microscopy/ spectroscopy, STED, SEM, and optical interformerty. He also studies RNA single molecule profiles with AFM and neuronal protein binding with actin.
Selected Cancer-Related Publications:
Sharma S, Santiskulvong C, Bentolila L, Rao J, Dorigo O, Gimzewski JK, Bentolila LA. Correlative nanomechanical profiling with super-resolution F-actin imaging reveals novel insights into mechanisms of cisplatin resistance in ovarian cancer cells. Nanomedicine. 2012 Jul;8(5):757-66. Epub 2011 Oct 22
Cross SE, Jin YS, Lu QY, Rao J, Gimzewski JK. Green tea extract selectively targets nanomechanics of live metastatic cancer cells. Nanotechnology. 2011 May 27;22(21):215101. Epub 2011 Mar 30
Cross SE, Jin YS, Tondre J, Wong R, Rao J, Gimzewski JK. AFM-based analysis of human metastatic cancer cells. Nanotechnology. 2008 Sep 24;19(38):384003. Epub 2008 Aug 12
Cross SE, Jin YS, Rao J, Gimzewski JK. Nanomechanical analysis of cells from cancer patients. Nat Nanotechnol. 2007 Dec;2(12):780-3. Epub 2007 Dec 2
Reed J, Mishra B, Pittenger B, Magonov S, Troke J, Teitell MA, Gimzewski JK. Single molecule transcription profiling with AFM. Nanotechnology. 2007 May 9;18(4):44032.